A.R. Pettitt, S. Barrington, N. Kalakonda, U.T. Khan, et al.  

NCRI PETREA TRIAL: A PHASE 3 EVALUATION OF PET- GUIDED, RESPONSE-ADAPTED THERAPY IN PATIENTS WITH PREVIOUSLY UNTREATED, ADVANCED-STAGE, HIGH-TUMOUR-BURDEN FOLLICULAR LYMPHOMA

PETReA is the first trial in FL to stratify patients for separate questions based on post‐induction PET status.

H. Tilly, C. Flowers, J.W. Friedberg, C. Herbaux, et al. 

POLARIX: A PHASE 3 STUDY OF POLATUZUMAB VEDOTIN (POLA) PLUS R-CHP VERSUS R-CHOP IN PATIENTS (PTS) WITH UNTREATED DLBCL
Enrolment began Nov 2017. This trial is currently recruiting, and plans to enrol 875 patients in 24 countries.

J. Zhu, Y. Song, S.D. Smith, O.A. O'Connor, et al.

PHASE III RANDOMIZED STUDY OF ENZASTAURIN/R- CHOP VS PLACEBO/R-CHOP IN FRONTLINE HIGH RISK DIFFUSE LARGE B CELL LYMPHOMA PATIENTS WITH GENOMIC BIOMARKER DGM1 (ENGINE STUDY)

The study is ongoing with 53 sites open in the US and China. As of 22 Feb 2019, 78 patients have been randomized. Clinical trial information: NCT03263026.

J.C. Villasboas, C.B. Reeder, H.W. Tun, N.L. Bartlett, et al. 

THE DIAL STUDY (DUAL IMMUNOMODULATION IN AGGRESSIVE LYMPHOMA): RANDOMIZED PHASE 2 TRIAL OF VARLILUMAB PLUS NIVOLUMAB IN RELAPSED/REFRACTORY AGGRESSIVE B-CELL LYMPHOMAS

The trial is registered (NCT03038672) and open to participation to members of the Experimental Therapeutics Clinical Trials Network (ETCTN) and Early Drug Development Opportunity Program (EDDOP).

T.E. Cummin, J. Caddy, K. Mercer, T. Maishman, et al. 

ACCEPT: A PHASE IB/II COMBINATION OF ACALABRUTINIB WITH RITUXIMAB, CYCLOPHOSPHAMIDE, DOXORUBICIN, VINCRISTINE AND PREDNISOLONE (R-CHOP) FOR PATIENTS WITH DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL)

The trial is coordinated by the CRUK Southampton Clinical Trials Unit. This is an investigator initiated study that has been granted free access to investigational medicinal product, trial management and translational study support through a grant from Acerta Pharma B.V. (IST‐LY‐801) and has endorsement from Cancer Research UK (CRUKDE/16/006). Trial registration: ISRCTN11965217 NCT0357130

P. Porcu  Y. Kim, P. Zinzani, H. Sicard, H.A. Azim Jr, M. Bagot

TELLOMAK: T-CELL LYMPHOMA ANTI-KIR3DL2 THERAPY: AN OPEN LABEL, MULTI-COHORT, MULTI- CENTER, INTERNATIONAL PHASE II STUDY EVALUATING THE EFFICACY AND SAFETY OF IPH4102 ALONE OR IN COMBINATION WITH CHEMOTHERAPY IN PATIENTS WITH ADVANCED T-CELL LYMPHOMA

A biomarker‐stratified design is applied in cohorts 2‐5 using a Simon 2‐stage design to inform on the activity of assigned treatment according to KIR3DL2 expression. In total, approximately 140‐260 patients will be recruited across 30‐40 sites in the US and Europe.